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Unlock Mitochondrial Vitality with MOTS-c
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c), a 16-amino-acid peptide encoded by the mitochondrial genome, acts as an "exercise mimetic" by translocating to the nucleus under metabolic stress to regulate genes involved in energy homeostasis, inflammation, and cellular repair. Naturally produced in tissues like skeletal muscle and detectable in plasma (with levels declining up to 50% by age 60), it mimics the benefits of physical activity to combat age-related decline. Administered via subcutaneous injection, MOTS-c shows promise for metabolic optimization, positioning it as an exciting frontier in longevity and wellness therapies.
Enhanced Metabolic Flexibility and Insulin Sensitivity: Activates AMPK pathways to boost glucose uptake in skeletal muscle and suppress hepatic gluconeogenesis, reducing insulin resistance by 20-30% in high-fat diet models and improving glycemic control in gestational diabetes—preclinical data suggest up to 25% better glucose tolerance, with potential to prevent type 2 diabetes progression in at-risk populations.
Promotes Fat Metabolism and Weight Management: Inhibits fat accumulation while enhancing fatty acid oxidation, leading to 10-15% reductions in body weight and visceral fat in obese animal models—early human analogs like CB4211 show promise in NAFLD trials for lowering liver fat and triglycerides, supporting sustainable obesity interventions.
Boosted Energy Production and Exercise Capacity: Restores mitochondrial respiration and ATP synthesis, increasing endurance and muscle performance—exercise elevates circulating MOTS-c by 20-50% in humans, with correlations to greater lower-body strength and lean mass gains in breast cancer survivors post-training.
Anti-Inflammatory and Cardioprotective Effects: Suppresses cytokines like IL-6 and protects against ischemia-reperfusion injury, reducing cardiac hypertrophy and restoring heart function in diabetic models—2025 studies highlight its role in alleviating lung injury post-cardiopulmonary bypass via glycolysis enhancement.
Anti-Aging and Bone Health Support: Mitigates age-related metabolic dysfunction and osteoporosis by inhibiting osteoclast activity and promoting osteogenesis, with up to 20% bone density preservation in ovariectomized models—extends potential to Alzheimer's prevention via nuclear gene regulation and reduced neurodegeneration risks.
Grounded in 2025 preclinical advances and pilot trials like those for CB4211 in NAFLD (NCT03998514), MOTS-c represents a cutting-edge tool for mimicking exercise benefits without the sweat—with analogs showing good tolerability.
Wellness Store Disclaimer: We don't sell or prescribe medications. Instead, we connect you to licensed professionals who can guide your journey responsibly.
Because we are not the medical provider, there is a $20 clinical consult fee that is handled directly by the medical group during your intake—similar to a telehealth visit. Once the clinician approves your case and issues your prescription, that $20 fee runs automatically. This fee is separate from your Destination Regen Wellness Store Order. However, a $20 credit will automatically be applied in your cart to offset this required fee.
